| Sample Preparation in Genomics
Pall manufactures membranes for the purification and concentration of biomolecules that exhibit extremely high yields with low biomolecule binding. We incorporate these membranes into devices that use fast, gentle methods and minimize handling to protect your valuable samples. Our attention to product quality and performance is expressed in reproducible results and pure samples for downstream processing.
For concentration and purification steps requiring ultrafiltration, we offer Omega™ modified polyethersulfone membrane. This membrane is well documented for low non-specific protein and DNA binding, high recoveries, and superior chemical and physical properties.
For applications such as lysate cleaning, drug binding studies and bead-based assays, choose Bio-Inert® modified Nylon 6,6, GHP hydrophilic polypropylene, or Supor® modified polyethersulfone membrane, all of which are formulated for low binding and low extractables.
Pall has developed unique membrane technology, in the form of Mustang™ anionic and cationic membrane adsorbers, which allows purification of nucleic acids and proteins using ion exchange chromatography. The Mustang product line is already established as the technology of choice for nucleic acid removal from process streams, such as part of DNA clearance from therapeutic products like vaccines. The utility of Mustang membrane adsorber modules has also been demonstrated for purification of plasmid DNA, for use as a gene therapy product.
For single sample or low throughput applications, Pall's centrifugal devices provide simple, fast concentration of samples from 50 μL to 60 mL, with recoveries typically greater than 90%. For high throughput applications, choose Pall filter plates. Each of our filter plate platforms targets specific application challenges.
Detection in Genomics
Detection techniques are important for interpreting results in all areas of genomics research and molecular diagnostic applications. As sample sizes become smaller and more valuable, the need intensifies for highly sensitive detection platforms that exhibit extremely low background. Our inspiring portfolio of membranes and materials provides the superior sensitivity you need to detect minute genomic samples. These products are proven and trusted for gene expression analysis.
Pall manufactures all of our membranes to the strictest quality standards, assuring consistent performance from lot to lot and blot to blot. Biodyne® nylon membranes are available with a neutral charge, positive charge, or negative charge to meet the needs of various techniques. These membranes can be efficiently stripped and reprobed, and perform optimally with all detection systems. BioTrace™ NT is a pure, unsupported nitrocellulose membrane that is strong and durable, and features high nucleic acid binding capacities.
For increased throughput, choose our filter plates for various biomolecule-binding assays. Top | 
